Aiming at the poor plugging performance of conventional bridge plug plugging material or the problem of repeat leakage in the drilling process of fractured reservoir, a kind of shearing resistance sealing agent DLJ5 was synthesized by the adding of hectorite. The microstructure of DLJ5 was researched by laser particle size analyzer and diffractometer. The swelling property, shearing resistance property, compatibility with drilling fluid and plugging performance were evaluated through lab tests. The results show that the initial average particle size of sealing agent DLJ5 is 204.5 μm. The internal double network structure with organic and inorganic can improve the strength of sealing agent. The swelling ratio of sealing agent DLJ5 is 35.52 in the simulation formation water of 50 ℃. The sealing agent has good shearing resistance properties and good compatibility with Changqing drilling fluid. The sealing agent also has good plugging property in high salinity reservoir. The shearing resistance sealling agent has broad application prospects in the drilling of fractured reservoir.